"We are on the verge of a revolution in medicine: understanding, treating, and ultimately preventing the causes of degenerative aging. But medical revolutions only happen if we all stand up in support of funding and research. We did it for cancer. We're doing it for Alzheimer's. We can do it for aging - and create an era of longer, healthier lives!"

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The Causes of Aging
Accumulating AGEs
Buildup of Amyloid Between Cells
The Failing Immune System
Declining Lysosomal Function
Mitochondrial DNA Damage
Senescent Cells
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Required Reading
Calorie Restriction
The Community, Visualized
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Engineered Negligible Senescence
Envisaging a World Without the FDA
Healthy Life Extension Explained
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Longevity Meme Newsletter
The Odds of Human Longevity Mutations
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Stem Cells, Regenerative Medicine
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What is Anti-Aging?

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Recent Entries

  • The Conservative View of Progress in Applied Cancer Research
  • More on Stem Cell Technology and the Rise of Medical Tourism
  • Resting Metabolic Rate and Aging, Another of Metabolism's Complexities
  • Capabilities in Stem Cell Science Are Advancing Rapidly
  • Incentives and Cryonics
  • Videos From the Foresight 2010 Conference
  • A Steady Flow of New Donors at the Methuselah Foundation
  • Manipulating Fat in the Context of Slowing Aging
  • On Medical Tourism For Stem Cell Therapies
  • Cells, Hearts, and Brains
  • Rapamycin Research Rolls Onward
  • Reversing Blindness in Retinitis Pigmentosa With Stem Cells
  • The Body Does Work to Break Down Damaging Aggregates
  • A Few Cancer Stem Cell Articles
  • The Latest on Mitochondrial Uncoupling
  • Longevity Research at the Science Network
  • Journalists Are In the Business of Gathering Eyeballs, Not Truth
  • @ging, a New Aging Science Blog
  • Redefining Bionics Again
  • Encouraging Transparency in Life Science Fundraising

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    April's CR Diary
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    grailsearch.org
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    Fight Aging! is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite Fight Aging! content in any way you see fit, the only requirements being that you (a) link to the original, (b) attribute the author, and (c) attribute Fight Aging!.

  • Monday, February 2, 2004

    The 300: First Draft

    The Methuselah Foundation will soon be beginning a new initiative to gain philanthropic donors prepared to commit $25,000 over 25 years to the Methuselah Mouse Prize and other innovative projects designed to encourage real anti-aging research. Taking inspiration from the 300 who stood at Thermopylae during the Persian Wars, these donors will be honored and their names remembered. One possibility is for their names to be inscribed into the Long Now Clock, a construction designed to survive for 10,000 years.

    For my part in this project, I've been looking at how to present this idea to the world. Here is my first draft:

    Thermopylae

    Honor to those who in their lives
    have defined and guard their Thermopylae.
    Never stirring from duty;
    just and upright in all their deeds,
    yet with pity and compassion too;
    generous when they are rich, and when
    they are poor, again a little generous,
    again helping as much as they can;
    always speaking the truth,
    yet without hatred for those who lie.

    And more honor is due to them
    when they foresee (and many do foresee)
    that Ephialtes will finally appear,
    and that the Medes in the end will go through.

    Constantine P. Cavafy (1903)

    In 484 BC, 300 noble Spartans changed the course of history. They faced an overwhelming and apparently undefeatable Persian army, but they stood and carried out their chosen obligation in the pass at Thermopylae.

    After treachery, and with brute force, the enormous Persian force under Xerces eventually took the pass. The delay allowed the Greek city states time to organize, however. Later that year, the Greeks turned the tide of the Persian Wars at the Battle of Salamis. Without the bravery, sacrifice and obligation of the 300 Spartans, this would not have happened. Today, thousands of years later, their names and deeds are still remembered, and rightly so.

    Today, we all face a different sort of overwhelming enemy: the aging process. It comes for us all, seemingly unbeatable like Xerces' Persians. We fight back as best we can with science, research and better medicine, but like the Greeks, aging science is underfunded, disorganized and in need of time.

    Can we beat back aging for long enough to develop therapies, preventions and cures for its degenerative effects in our lifetime? Can we really defeat aging once and for all? We are all involved, and we will all suffer the same fate as those who lose in battle if we do not rally and win this war.

    The Methuselah Foundation is seeking modern Spartans; 300 noble men and women to stand in the pass of aging research and win more time for the forces of science. Each Spartan pledges $1000 a year for the next 25 years to the Foundation, these funds to be used for innovative and influential projects in anti-aging research like the Methuselah Mouse Prize.

    The first Spartans have already come forward and made themselves known. Together we can change the course of history; we can win time for science to organize and defeat aging in our lifetimes. Come and join our ranks: our names and deeds, like those who stood at Thermopylae, will be remembered forever!

    Posted by Reason

     
    Share |

    Posted by: Methuselan at February 3, 2004 4:32 AM

    Reason - This is wonderful. Already, five non-wealthy individuals have given up the equivalent of a daily trip to Starbucks in order to support this initiative. It will only take another 33 individuals to step forward and join the ranks in order to prospectively push the prize fund above - One MILLION Dollars.

    For those considering locking arms with us in this, you can commit today, but don't need to actually make the initial donation until the end of 2004. This will give you plenty of time to prepare.

    If you've already donated to the Prize, (and many have!) your prior donations count toward the $25,000 commitment.

    David Gobel

    [Posted by: Methuselan at February 3, 2004 4:32 AM]

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