ScienceBlog reports on efforts to create genetic tweaks to prevent obesity. In this study, mice with ramped up metabolisms that burn fat at a higher rate not only stay thinner, but also live longer: "despite their svelte appearance, beta/beta mice actually eat more food and are no more active than their genetically normal littermates ... the white adipose tissue, which is normally reserved for fat storage, had actually been converted into fat burning cells in beta/beta mice." You may recall that scientists recently overturned the common wisdom on metabolism and longevity - mice with more active metabolisms have been shown to live longer, possibly due to a lower rate of free radical creation.
02
Aug
2004
Genetics Of Metabolism And Longevity
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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