(From News-Medical.net). Understanding exactly how Alzheimer's disease develops in its earliest stages is a very necessary first step on the path to early detection and prevention. Researchers are now looking beyond the characteristic amyloid plaques to uncover the causative biochemistry: "Early Alzheimer's disease may be precipitated by a 'traffic jam' within neurons that causes swelling and prevents proper transport of proteins and structures in the cells ... we decided to look at mouse models of Alzheimer's disease early in their life, before plaque formation, to see if we could detect early evidence of abnormal axonal transport ... What we saw quite early in the life of those animals - well before any plaque deposition - were obvious axonal defects."
27
Feb
2005
On Early Alzheimer's Development
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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