A long article from RedNova explains the Grandmother Hypothesis as it relates to the evolution of human life span and reproductive capabilities. Finding an explanation for the comparatively long human life span is one part of wider longevity research - we live longer than other mammals of the same size, but we do know know why this is the case. "There is little question that positive selection has acted on genes that increase lifespan. [However] there is still considerable debate as to whether or not prolonged lifespan has been selected to ensure the survival of offspring (Mother Hypotheses) or to increase the reproductive success of those offspring (Grandmother Hypotheses)."
28
Feb
2005
On The Grandmother Hypothesis
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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