(From Science Blog). A study in mice shows that delayed motherhood lowers the life span of children in mice: "Negative effects of late maternal age in women, such as abnormal numbers of chromosomes in their children, are well known. However, other potential negative effects on offspring from delayed motherhood have been only anecdotal. ... a team of reproductive biologists [presents data showing] that delayed motherhood in mice results in decreased life expectancy and reduced body weight of their offspring." This would seem to reinforce theories of aging based on accumulated genetic damage - if this damage in germ cells reduces the life span of your children, what is the same damage in other cells doing to your own body?
21
May
2005
Older Mother, Shorter Life
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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