Why do stem cells - and thus our ability to heal - falter in effectiveness as we age? This Newswise release outlines the results that suggest "this behavior may be regulated by genetic mechanisms found in most human cells ... The current thinking is that there must be some unique 'stemness' gene that no other cell expresses, but what we found is that what makes stem cells special -- their ability to renew themselves and differentiate into other tissue types -- may be attributed to fundamental mechanisms of cell physiology common to all cells. ... The difference between those robust, self-replicating young [stem cells] and older cells appears to be the degree of expression of these two regulatory genes governing fundamental cell physiology." Might it be possible to restore old stem cells to youthful vigor?
02
May
2005
"Stemness" And Stem Cell Aging
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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