An article from Genomics & Proteomics takes a broad look at changes in gene expression with aging - and hints of ways in which to intervene in the process. Interestingly, there is mention of developing biomarkers for physiological age: "We just now have molecular markers for aging in the kidney. If I did the same thing, we could have molecular markers for aging in the muscle, liver, or skin. These markers don't tell how many years you've lived; they tell your relative health. You could turn these into terrific clinical markers, and you would know whether someone is 40 and looks like they're on a bad trajectory, or if they're 80 and you could treat them as a 40-year-old." The current absence of meaningful biomarkers makes it difficult to usefully discuss the results of therapies.
23
Jun
2005
Gene Expression And Aging
Comments
Post a comment; thoughtful, considered opinions are valued. Please note that comments incorporating ad hominem attacks, advertising, and other forms of inappropriate behavior are likely to be deleted.
First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
Archives and Feeds
- Monthly News and Blog Archives
- Newsletter Archive
- Using the Fight Aging! Content Feeds
- Fight Aging! on the Kindle
Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
Creative Commons
- All of Fight Aging!, with the exception of the introductory articles, is published under the Creative Commons Attribution 3.0 license. In short, this means that you are encouraged to republish and rewrite Creative Commons licensed Fight Aging! content in any way you see fit, the only requirements being that you (a) link to the original, (b) attribute the author, and (c) attribute Fight Aging!.