There is a great deal of overlap between research into aging and cancer; both result from the same mechanisms of cellular life span. The BBC reports on the relationship between cellular senescence and certain cancers: senescence, "which is part of aging and is controlled by certain genes, results in cells - and tumours - failing to respond to normal growth signals. Men with prostate cancer lack the genes that appear to mediate this process ... [a study] in mice suggests correcting this could be a way to prevent prostate tumour growth." In the recent past, another group "found senescence kept human moles in a non-cancerous state for year, and without it they could develop into a dangerous form of skin cancer called malignant melanomas in the lab. Similarly, a team from Germany showed that cellular senescence is capable of blocking a cancer called lymphoma in mice."
07
Aug
2005
More From The Aging-Cancer Overlap
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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- Newsletter Archive
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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