From details of the recent Fanconi anemia research and insight into DNA repair, it is interesting to note that "We have known for decades that patients with Fanconi anemia have chromosomes that break easily ... we can now suggest that DNA double-strand breaks are the lesions that underlie the pathology of this disease." Digging into past material at Fight Aging!, we find "DNA double strand breaks are regarded as one of the primary causes of cancer." If you're of a scientific mindset, you should find the first and second parts of a conversation on aging theories between Robert Bradbury, Aubrey de Grey and Joao Magalhaes to be relevant and interesting: "DNA double strand breaks are bad."
Link: http://www.eurekalert.org/pub_releases/2005-08/nioa-gds081805.php