NorthernStar Online looks at the Strategies for Engineered Negligible Senescence (SENS) and the work of biomedical gerontologist Aubrey de Grey: "Imagine living to age 50 sans wrinkles, without relinquishing any youthful gaiety, to maybe even see your great-granddaughter's high school education. Sounds implausible, but science is working on it. ... Approaching aging via engineering, SENS is designed to deal periodically with routine damage done to human cells, keeping it at a level low enough to prevent pathology. ... I use the phrase ['War on Aging'] to describe the period starting when we get results in the laboratory with mice that are impressive enough to make people realize that life extension is possible, and ending when the first effective therapies for humans are developed. I estimate that the War On Aging will start 10 years from now, subject to funding of research, and will last for 15 years, but this latter estimate is extremely speculative."
06
Mar
2006
The Mainstream Discovers SENS
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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