Nice work by the Buck Institute researchers, reported in Newswise: "There are approximately 200 mice at the Buck Institute that should have the symptoms of Alzheimer's disease (AD). But these mice, despite the fact that their brains are loaded with the sticky deposits commonly associated with the neurodegenerative disease, have normal memories, and show no signs of the brain shrinkage and neuron damage commonly associated with AD. ... Buck scientists saved the mice from their prescribed fate by a blocking a newly discovered molecular pathway ... AD may be a more subtle disease, which develops when the normal process of nerve signaling goes out of balance. The alteration we produced allowed normal neuron connections to occur, even in the presence of the senile plaques."
24
Apr
2006
New Alzheimer's Research
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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