The breadth of new approaches to developing the next generation of Alzheimer's therapies is a good thing; diversity and dynamism together indicate progress in medical science. Via the Globe and Mail: "TMP21 protein inhibits the production of a toxin in the brain called beta-amyloid, also known as Abeta, the main culprit in destroying brain cells in Alzheimer's patients. ... The protein appears to be very specific and only effects the toxin, but doesn't effect normal cell function." Attacking amyloid beta is one way forward, though scientists have shown that amyloid is not necessarily the real culprit. It's the most noteworthy late stage of a process best halted earlier, but at this point, too many people are suffering for lack of any port in the storm - a breadth of approaches is vital.
29
Apr
2006
Suppressing Amyloid Beta
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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