26
Oct
2006
Inside a Stem Cell Trial
Permalink | View Comments (0) | Post Comment | Posted by Reason

The Scientist takes us inside one of a number of trials of first generation autologous stem cell therapy aimed at regenerating the damage of heart disease: "More than 10 years ago, researchers isolated endothelial progenitor cells from the ranks of CD34+ cells derived from bone marrow or mobilized to the peripheral blood. This provided a rationale for the idea that CD34+ cells could induce angiogenesis. Human CD34+ cells have been shown to induce angiogenesis and improve cardiac function in a rat model of myocardial ischemia, and CD31+ cells, the pig analog of CD34+ cells, have been shown to do the same in that species. The Phase II trial Bergman is enrolled in follows a successful Phase I trial of the method in humans, using direct injection following catheterization because it can precisely target areas of ischemia."

Link: http://www.the-scientist.com/article/home/24908/

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