Scientists are people like the rest of us, and people have issues with change - even those working to create that change. So all fields of science have a certain inherent degree of dogma versus heresy; on the one hand, funding organizations want the best chance of placing resources where they will do the most good, and so support the consensus view. On the other hand, leaps in understanding come from challenges to the orthodoxy. A healthy field is rife and energetic with heresy - where many new and different ideas are tested by the scientific method. This Post-Gazette pieces gives a taste of how this all looks in Alzheimer's research: "For more than 20 years, the leading theory has held that sticky blobs in the brain called amyloid plaques cause Alzheimer's. Because that idea has numerous problems, doubters argued that the plaques might be innocent bystanders to the real, 'upstream' culprit. If so, targeting the plaques, or the rogue protein called beta-amyloid that forms them, would do nothing to help [those] who suffer from Alzheimer's."
19
Nov
2006
Debates in Alzheimer's Science
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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