"We are on the verge of a revolution in medicine: understanding, treating, and ultimately preventing the causes of degenerative aging. But medical revolutions only happen if we all stand up in support of funding and research. We did it for cancer. We're doing it for Alzheimer's. We can do it for aging - and create an era of longer, healthier lives!"

  
Search

Required Reading
Activism and Advocacy
Calorie Restriction
The Community, Visualized
Cryonics
Envisaging a World Without the FDA
Healthy Life Extension Explained
Introductory Articles
Longevity Meme Newsletter
The Most Important Debate
Stem Cells, Regenerative Medicine
SENS, Negligible Senescence
What is Anti-Aging?

Initiatives
Biogerontology Research Foundation
LifeStar Institute
Methuselah Foundation
Mprize for Longevity Research
Science Against Aging (Translate)
SENS Foundation

On the Causes of Aging
Accumulating AGEs
The Failing Immune System
Junk in the Lysosome
Mitochondrial Free Radicals
Senescent Cells
Other Causes of Aging

Benefiting From Medical Research
How to Read Scientific Research
Researching Therapies and Clinical Trials

Objections Answered
Boredom
Inequality and Economics
Overpopulation
Stagnation
Being Older for Longer?
What About Retirement?

Recent Entries

  • Subtleties of Calorie Restriction and Evolution
  • Signs of the Times: Engineered Organs in the Popular Press
  • Genescient Envisioned as Sirtris++
  • Help the Immortality Institute Fund Research Into Laser Ablation of Lipofuscin
  • The Singularity's Time in the Sun
  • Deciphering the Machine By Pulling Out Cogs and Flipping Switches
  • Scientific American on Alzheimer's Research
  • The Downward Spiral
  • A Male-Only Longevity Mutation in Mice
  • Cryonics and Economic Incentives
  • Bid in a Charity Auction For a Portrait of Aubrey de Grey
  • You Have To Do Better Than That
  • Failing Memory and the Failing Immune System: Reversible?
  • A New Spanner to Throw Into the Works of Cancer
  • The Benefits of Falling Costs in Biotechnology
  • SENS 4: Early Registration and Abstract Submission Deadline Approaches
  • A Cautionary Tale and a Point of Principle
  • On the 2009 AGE Conference
  • An Update on Decellularization / Recellularization
  • Accumulating Mitochondrial DNA Damage: More Harm or Less Repair?

    Blogs of Interest
    Accelerating Future
    Ageing Research
    Anti-Ageing Research
    Alcor News
    Al Fin Longevity
    April's CR Diary
    Andart
    Biosingularity
    CRON Diary
    Cryonics Society
    Depressed Metabolism
    Distributed Republic
    Ethical Technology Blog
    Existence is Wonderful
    Future Current
    FuturePundit
    grailsearch.org
    green light go
    In Search of Enlightenment
    Longevity Science
    Marginal Revolution
    Metamagician and the Hellfire Club
    Metamodern
    Methuselah Foundation Blog
    Mises Economics Blog
    Nanodot
    Ouroboros
    Overcoming Bias
    Pimm - Partial immortalization
    Responsible Nanotechnology
    ScienceBlogs
    Sentient Developments
    Singularity Hub
    Singularity Institute Blog
    The Loom
    The Speculist
    Transumanar

    Archives (Monthly)

    July 2009
    June 2009
    May 2009
    April 2009
    March 2009
    February 2009
    January 2009
    December 2008
    November 2008
    October 2008
    September 2008
    August 2008
    July 2008
    June 2008
    May 2008
    April 2008
    March 2008
    February 2008
    January 2008
    December 2007
    November 2007
    October 2007
    September 2007
    August 2007
    July 2007
    June 2007
    May 2007
    April 2007
    March 2007
    February 2007
    January 2007
    December 2006
    November 2006
    October 2006
    September 2006
    August 2006
    July 2006
    June 2006
    May 2006
    April 2006
    March 2006
    February 2006
    January 2006
    December 2005
    November 2005
    October 2005
    September 2005
    August 2005
    July 2005
    June 2005
    May 2005
    April 2005
    March 2005
    February 2005
    January 2005
    December 2004
    November 2004
    October 2004
    September 2004
    August 2004
    July 2004
    June 2004
    May 2004
    April 2004
    March 2004
    February 2004
    January 2004

    Creative Commons License
    Attribution, noncommercial, no derivative works. Play nice.

  • Thursday, May 22, 2008

    Engineering an End to Aging

    Michael Anissimov is back to writing on the topic of healthy life extension once more, and a good thing too. As more writers craft works of common sense on aging and advocacy for longevity science, it becomes easier to raise significant funding for research and development aimed at repairing the damage of aging. Raising the tide of awareness to float the boats of endeavor is a labor in and of itself - but it must happen if we are to succeed.

    You'll find Anissimov's latest piece hosted at the Immortality Institute:

    Age-defying creams and lotions, esoteric herbs and elixirs, botox and plastic surgery, what do they all have in common?

    None of them will actually increase your lifespan. Usually, they're snake oil. At best, they improve external appearance without actually extending life. We deserve better, and we'll need it if we want to live longer than the typical four score and ten years.

    ...

    Enter Dr. Aubrey de Grey, a biogerontologist from the UK, and his "strategies for engineered negligible senescence" (SENS) plan. Instead of exclusively studying the complex biochemical processes of aging in detail, as in gerontology, or ameliorating the worst symptoms of age-related decline, as in geriatrics, de Grey and his supporters advocate an "engineering approach" to aging, which asks: what are the main categories of age-related biochemical damage, and how can we fix them? The idea is not to eliminate the sources of age-related damage, but fix the damage fast enough that it doesn't accumulate to cause health problems. This is far easier than deciphering all the intricacies of the biochemistry of aging.

    Go and read the whole thing. One of the pleasant aspects of this new publishing paradigm we've engineered for ourselves on the web is that there is less of a need to forge your work, complete in every aspect, prior to presenting it. One can publish early and iterate the publication often, which I think tends to lead to a better result. In that vein, Anissimov is soliciting constructive criticism for the next iteration:

    Check it out, and let me know if there’s any way it might be improved or modified.

    Aging sucks! Let’s end this terrible disease, and let people live as long as they desire.

    Posted by Reason at May 22, 2008 6:56 PM | TrackBack (0)

    Post a comment; thoughtful, considered opinions are valued. Please note that comments incorporating ad hominem attacks, advertising and other forms of inappropriate behavior are likely to be deleted.










    Remember personal info?