"We are on the verge of a revolution in medicine: understanding, treating, and ultimately preventing the causes of degenerative aging. But medical revolutions only happen if we all stand up in support of funding and research. We did it for cancer. We're doing it for Alzheimer's. We can do it for aging - and create an era of longer, healthier lives!"

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The Causes of Aging
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  • The Conservative View of Progress in Applied Cancer Research
  • More on Stem Cell Technology and the Rise of Medical Tourism
  • Resting Metabolic Rate and Aging, Another of Metabolism's Complexities
  • Capabilities in Stem Cell Science Are Advancing Rapidly
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  • Videos From the Foresight 2010 Conference
  • A Steady Flow of New Donors at the Methuselah Foundation
  • Manipulating Fat in the Context of Slowing Aging
  • On Medical Tourism For Stem Cell Therapies
  • Cells, Hearts, and Brains
  • Rapamycin Research Rolls Onward
  • Reversing Blindness in Retinitis Pigmentosa With Stem Cells
  • The Body Does Work to Break Down Damaging Aggregates
  • A Few Cancer Stem Cell Articles
  • The Latest on Mitochondrial Uncoupling
  • Longevity Research at the Science Network
  • Journalists Are In the Business of Gathering Eyeballs, Not Truth
  • @ging, a New Aging Science Blog
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  • Encouraging Transparency in Life Science Fundraising

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  • Tuesday, December 2, 2008

    From Understanding Aging: Destroying Lipofuscin and Destroying Cancer

    We should all thank Jeriaska of Future Current for providing such a fine service in writing up and publishing presentations, interviews, and lectures from conferences of interest to the transhumanist and healthy life extension communities. Two of the latest are from the Understanding Aging conference hosted earlier this year by the Methuselah Foundation:

    Natural Cancer Resistance in Mice and in Humans

    The main concept for this project is very simple. This idea, that we may have natural resistance to cancer present in our body at all times, is not a new idea. It has been proposed for over a hundred years. In other words, the reason that we are sitting here cancer-free is not because we’re lucky, it is because we may have an innate system in our body to protect us - in other words, to get rid of cancer cells. As we get older, this protection may get weaker. That balance between the generation of cancer cells on a continuous basis can overtake the ability of your body to get rid of them

    If you are already familiar with Zheng Cui's work, this presentation provides some very interesting additional data. If not, you might want to read the excellent introduction posted at the Methuselah Foundation blog.

    Unfocused Pulsed Lasers Selectively Destroy Lipofuscin

    The idea is lipofuscin is this aggregate of oxidized lipids and proteins that accumulates in autophagosomes or lysosomes. Lipofuscin itself we think is the problem. We think lipofuscin is sufficient to knock down autophagy as it accumulates. Eventually you get cells that are loaded with lipofuscin and the lysosomes cannot do their job of rejuvenating the cell. We think many aspects of aging are the result. If that is true, this is where the whole idea of "removing the garbage" comes in. We think the garbage itself is the problem, and if you can get rid of it we can make some serious inroads into conquering aging.

    If you found these items interesting, then I recommend you look over the online videos from the Understanding Aging conference.

    Posted by Reason

     
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