If we could shut down metastasis, cancer would be a far less dangerous proposition, open to a broader range of less harmful therapies: "Cancer metastasis, where the cancer spreads from its original location, is known to be responsible for 90% of cancer-related deaths. ... scientists have found that an enzyme called LOX is crucial in promoting metastasis ... Drugs to block this enzyme's action could keep cancer at bay ... The researchers studied breast cancer in mice, but are confident that their findings will apply to humans with other cancer types too. LOX (lysyl oxidase) works by sending out signals to prepare a new area of the body for the cancer to set up a camp. Without this preparation process the new environment would be too hostile for the cancer to grow. ... it was the first time one key enzyme has been identified as responsible for effectively allowing the cancer to spread. ... the next stage will be to find out if the LOX protein can be switched off to stop cancer spreading."
09
Mar
2009
Towards an End to Metastasis
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
Archives and Feeds
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- Newsletter Archive
- Using the Fight Aging! Content Feeds
- Fight Aging! on the Kindle
Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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