Seeking Common Cancer Mechanisms

(From the LEF News). Perhaps the largest hurdle facing cancer researchers is the sheer diversity of cancer biochemistry. If age-related cancer was very complex but unvaried, scientists would already have a cure in hand. Thus, one aspect of cancer science is the search for controllable, common biochemistry across many different types of cancer: "CXCR4 is over-expressed in greater than 75% of cancers, including breast, ovarian, lung, colon, prostate, kidney, melanoma, brain, esophageal, and pancreatic - as well as numerous forms of leukemia, and childhood cancers such as acute lymphocytic leukemia and neuroblastoma. Northwest Biotherapeutics previously completed and reported on several preclinical studies using monoclonal antibodies to block CXCR4 receptor function, and reported significant inhibition of cancer cell proliferation, motility and invasion in multiple preclinical models both in vitro and in vivo."

Link: http://www.lef.org/news/LefDailyNews.htm?NewsID=4228&Section=DISEASE

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