Stem Cells Versus Kidney Damage
This press release shows the potential for stem cell transplants to spur regeneration of the kidney: "Cytori Therapeutics, Inc. finds adipose tissue-derived stem and regenerative cells (ADRCs) significantly reduce mortality and improve renal function in an acute kidney injury model ... Acute kidney injury is a tremendous medical and financial burden to the healthcare system due to high mortality rates and the lack of effective therapies beyond supportive treatments. ... acute kidney injury was induced in 29 preclinical research subjects by occluding blood flow into and out of both kidneys for 38 minutes. Twenty minutes after reperfusion of the kidneys, ADRCs or saline only were injected intra-arterially. All subjects were assessed daily for 7 days for markers of kidney function (serum creatinine and blood urea nitrogen) and survival. After seven days, 100% of ADRC-treated preclinical subjects survived compared to only 57% in the control group. The ADRC-treated subjects also showed statistically significant improvements in kidney function ... In addition, substantial improvement in the histologic structure within the kidney was observed ... This study suggests that ADRCs significantly accelerate renal repair and preserve renal function, offering a potential therapeutic approach in renal reparative medicine."