Early Development, Moose, and Later Arthritis
From the New York Times: "In the 100 years since the first moose swam into Lake Superior and set up shop on an island, they have mostly minded their moosely business, munching balsam fir and trying to evade hungry gray wolves. But now the moose of Isle Royale have something to say - well, their bones do. Many of the moose, it turns out, have arthritis. And scientists believe their condition's origin can help explain human osteoarthritis - by far the most common type of arthritis, affecting one of every seven adults 25 and older and becoming increasingly prevalent. The arthritic Bullwinkles got that way because of poor nutrition early in life, an extraordinary 50-year research project has discovered. That could mean, scientists say, that some people's arthritis can be linked in part to nutritional deficits, in the womb and possibly throughout childhood. The moose conclusion bolsters a small but growing body of research connecting early development to chronic conditions like osteoarthritis. ... Nutrients, experts say, might influence composition or shape of bones, joints or cartilage. Nutrition might also affect hormones, the likelihood of later inflammation or oxidative stress, even how a genetic predisposition for arthritis is expressed or suppressed."
Link: http://www.nytimes.com/2010/08/17/health/research/17moose.html