Aging of Human Egg Cells Associated with Falling Oxygen Levels

Researchers here identify a possible proximate mechanism associated with the age-related decline of human fertility. It is a little early in the research process to say what might be made of this, or how it connects to the underlying causes of degenerative aging, however. Researchers have examined the sharp decline in egg quality in women 40 and older and found that egg damage is linked to oxygen-deprived cells. “More women are postponing childbearing, but with age, the cumulus cells that surround and nurture the eggs begin dying; we’ve found that this is caused by lack of oxygen. This follicular hypoxia triggers a cascade of biochemical changes in the cumulus cells. This may ultimately affect chromosomal abnormalities seen in eggs of older patients.” The researchers studied … Continue reading Aging of Human Egg Cells Associated with Falling Oxygen Levels