"We are on the verge of a revolution in medicine: understanding, treating, and ultimately preventing the causes of degenerative aging. But medical revolutions only happen if we all stand up in support of funding and research. We did it for cancer. We're doing it for Alzheimer's. We can do it for aging - and create an era of longer, healthier lives!"

Required Reading
Activism and Advocacy
Calorie Restriction
The Community, Visualized
Cryonics
Healthy Life Extension Explained
Introductory Articles
Longevity Meme Newsletter
Methuselah Foundation
Mprize for Longevity Research
Stem Cells, Regenerative Medicine
SENS, Negligible Senescence
What is Anti-Aging?

On the Causes of Aging
Accumulating AGEs
The Failing Immune System
Junk in the Lysosome
Mitochondrial Free Radicals
Senescent Cells
Other Causes of Aging

Objections Answered
Boredom
Inequality and Economics
Overpopulation
Stagnation
The Tithonus Error
What About Retirement?

Recent Entries

  • Thoughts on Engineered Longevity and Selfishness
  • A Little More On Preventing Decline in Liver Function With Age
  • The Quest for Clearly Understood Signifiers
  • The Endocrine System, Longevity, and Methionine
  • There Are Old People and Fat People, But Few Old Fat People
  • More Cryonics History From Depressed Metabolism
  • Attitudes of Aging Researchers To Healthy Life Extension
  • Three Decades From Now
  • On Stem Cells, Aging, and Latexin
  • IGF-1, FOXO and Telomeres at Ouroboros
  • An Interview With Dave Gobel of the Methuselah Foundation
  • Tear Down the FDA
  • Advancing Knowledge of Stem Cells in the Brain
  • On the Psychology of Longevity Advocacy
  • Casting an Eye Upon Alcor's Board
  • The Murky Depths of Parkinson's Disease
  • How To Tell Whether It's Working
  • Gregory Stock at Aging 2008
  • Preparation is Only Helpful When Done Before You Need It
  • Cancer and Immune System Proficiency

    Weblogs of Interest
    Accelerating Future
    Ageing Research
    Anti-Ageing Research
    Alcor News
    Al Fin Longevity
    April's CR Diary
    Andart
    Biosingularity
    CRON Diary
    Cryonics Society
    Depressed Metabolism
    Distributed Republic
    Ethical Technology Blog
    Existence is Wonderful
    Frontier Channel
    Future Current
    FuturePundit
    grailsearch.org
    Longevity Science
    Marginal Revolution
    Metamagician and the Hellfire Club
    Methuselah Foundation Blog
    Mises Economics Blog
    Nanodot
    Ouroboros
    Overcoming Bias
    Pimm - Partial immortalization
    Responsible Nanotechnology
    ScienceBlogs
    Sentient Developments
    Singularity Institute Blog
    The Loom
    The Speculist
    Tangled Bank
    Transumanar

      
    Search

    Archives (Monthly)

    August 2008
    July 2008
    June 2008
    May 2008
    April 2008
    March 2008
    February 2008
    January 2008
    December 2007
    November 2007
    October 2007
    September 2007
    August 2007
    July 2007
    June 2007
    May 2007
    April 2007
    March 2007
    February 2007
    January 2007
    December 2006
    November 2006
    October 2006
    September 2006
    August 2006
    July 2006
    June 2006
    May 2006
    April 2006
    March 2006
    February 2006
    January 2006
    December 2005
    November 2005
    October 2005
    September 2005
    August 2005
    July 2005
    June 2005
    May 2005
    April 2005
    March 2005
    February 2005
    January 2005
    December 2004
    November 2004
    October 2004
    September 2004
    August 2004
    July 2004
    June 2004
    May 2004
    April 2004
    March 2004
    February 2004
    January 2004

    Creative Commons License
    Attribution, noncommercial, no derivative works. Play nice.

  • « The Most Important Thing That Happened In 2007 | Main | Creating Wealth Versus Persuading Wealth »

    Wednesday, January 2, 2008

    It's the Fat...

    Here's a little experimental work to remind us all that, whatever the apologists for an abundance of body fat might like to be the case, it's just not good for health and longevity over the long term:

    Aging is associated with increases in fat mass (FM) and decreases in fat-free mass (FFM) that may affect physical capacity. However, it is not clear whether high FM or low FFM contribute more to a reduction in physical capacity.

    ...

    our results showed that percentage of FM was significantly associated with physical capacity (p <.01), whereas no such association was observed with FFM. Other variables such as physical activity level, number of self-reported diseases, and age were associated with physical capacity (all p <.01).

    ...

    FM was significantly and inversely correlated with physical capacity, whereas FFM was not associated when controlled for other potential confounding variables.

    There's a more than reasonable weight of science behind the bad things that excess fat cells do to your metabolism - such as act as a source of chronic inflammation, continually generating damage at the cellular and biochemical level that your body cannot repair. That's not even to talk about what "reduction in physical capacity" and the resultant lack of exercise does for your prospects:

    Exercise reduce the rate at which some of the cellular and biomolecular damage of aging accumulates, either by slowing the ongoing addition of new damage, or by modifying the processes of repair. In a future of rapidly advancing biotechnology, even a single additional year of time to wait for new therapies is a big deal.

    Letting years of future health slide away through simple negligence of the basics is a choice; many people make it. It just doesn't seem the smartest way forward.

    Posted by Reason at January 2, 2008 8:28 PM | TrackBack (0)

    Post a comment; thoughtful, considered opinions are valued. Please note that comments incorporating ad hominem attacks, advertising and other forms of inappropriate behavior are likely to be deleted.










    Remember personal info?