Randall Parker comments on the use of genetic screening to uncover compounds that affect longevity via the metabolism. "Some researchers have been comparing the pattern of gene expression found in mice on CR diets with the patterns of gene expression found in mice given a variety of drugs. Some already used drugs may induce a metabolic state that will extend life expectancy by the same mechanism that CR diets extend life expectancy." Several threads of research underway at the moment are extending our knowledge of the ways in which metabolism and the aging process interact and are controlled. This can only be a good thing - it brings us closer to early therapies that can effectively extend healthy life spans.
15
Aug
2004
FuturePundit On CR Mimetics
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
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- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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