Randall Parker comments on the use of genetic screening to uncover compounds that affect longevity via the metabolism. "Some researchers have been comparing the pattern of gene expression found in mice on CR diets with the patterns of gene expression found in mice given a variety of drugs. Some already used drugs may induce a metabolic state that will extend life expectancy by the same mechanism that CR diets extend life expectancy." Several threads of research underway at the moment are extending our knowledge of the ways in which metabolism and the aging process interact and are controlled. This can only be a good thing - it brings us closer to early therapies that can effectively extend healthy life spans.