The Gazette at John Hopkins University provides insight into how research into calorie restriction moves forward: "Calorie restriction has intrigued scientists for decades because it increases the life span of almost every species studied." Genetic screening allows scientists to establish a profile of changes caused by calorie restriction. This profile can then be compared with those produced by various compounds to try and narrow down the field of candidate drugs and drug targets in the body. "Our findings could be used to take a rational approach to designing drugs that mimic beneficial aspects of calorie restriction." Calorie restriction mimetics are a hot topic in medical research at the moment.
07
Sep
2004
Inside Calorie Restriction Research
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First Steps
The Causes of Aging
- Accumulating AGEs
- Buildup of Amyloid Between Cells
- The Failing Adaptive Immune System
- The Failing Innate Immune System
- Declining Lysosomal Function
- Mitochondrial DNA Damage
- Nuclear DNA Damage
- Buildup of Senescent Cells
- Other Causes of Aging
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Required Reading
- Calorie Restriction
- The Community, Visualized
- Cryonics
- Engineered Negligible Senescence
- Envisaging a World Without the FDA
- How to Argue for Longevity Science
- Introductory Articles
- The Odds of Human Longevity Mutations
- The Need For Activism and Advocacy
- Stem Cells, Regenerative Medicine
- Twelve Ways to Extend Mouse Life Span
- Transhumanism and Human Longevity
- The Vital Debate in Aging Research
- What is Anti-Aging?
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