The Gazette at John Hopkins University provides insight into how research into calorie restriction moves forward: "Calorie restriction has intrigued scientists for decades because it increases the life span of almost every species studied." Genetic screening allows scientists to establish a profile of changes caused by calorie restriction. This profile can then be compared with those produced by various compounds to try and narrow down the field of candidate drugs and drug targets in the body. "Our findings could be used to take a rational approach to designing drugs that mimic beneficial aspects of calorie restriction." Calorie restriction mimetics are a hot topic in medical research at the moment.