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Periodontitis and Amyloid-β, Another Good Reason to Take Better Care of Your Teeth

Periodontitis produces chronic inflammation that is associated with a raised risk of cardiovascular disease and worse cognitive decline in aging. At some point in the near future researchers will be able to control or eliminate the mouth bacteria that cause periodontitis, but for the moment we're all stuck with diligent maintenance as a primary strategy. Here is another good reason to keep up with that work:

The accumulation of amyloid-β (Aβ) plaques is a central feature of Alzheimer's disease (AD). First reported in animal models, it remains uncertain if peripheral inflammatory and/or infectious conditions in humans can promote Aβ brain accumulation.

Periodontal disease, a common chronic infection, has been previously reported to be associated with AD. Thirty-eight cognitively normal, healthy, and community-residing elderly (mean age, 61 and 68% female) were examined. Linear regression models (adjusted for age, apolipoprotein E, and smoking) were used to test the hypothesis that periodontal disease assessed by clinical attachment loss was associated with brain Aβ load using 11C-Pittsburgh compound B (PIB) positron emission tomography imaging.

After adjusting for confounders, clinical attachment loss (≥3 mm), representing a history of periodontal inflammatory/infectious burden, was associated with increased PIB uptake in Aβ vulnerable brain regions. We show for the first time in humans an association between periodontal disease and brain Aβ load. These data are consistent with the previous animal studies showing that peripheral inflammation/infections are sufficient to produce brain Aβ accumulations.

Link: http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.038

Comments

How long are we supposed to wait for this breackthrough? Periodontitis is one of the most persistently inflammatory producing condition that exists and nothing seem to curb it.

Posted by: angie at December 23rd, 2014 5:29 PM

I use an oral probiotic that likely helps periodontal disease. Use before bed after brushing. BLIS K12 Plus use a xylitol-based toothpaste.

My personal belief is that a person needs to do some research and just try some things...

Posted by: roger at December 24th, 2014 4:04 AM

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