Become a SENS Patron, Sign Up Today!

This year we're trying something a little different in our fundraising, with a longer term view. This is the time for it! Newly formed companies are now working on the first SENS therapies, and longer-term non-profit research projects are also underway. These initiatives will come to fruition some years from now: the SENS Research Foundation recently launched Project|21 with a five year timeline, for example. In 2017 we're looking for more members of our community to become SENS Patrons for the long term, by signing up for a recurring monthly donation to the SENS Research Foundation, and then keeping that going until the job is done and the first rejuvenation therapies are deployed.

It is never too late to set up a recurring monthly donation to support the work of the SENS Research Foundation. Make your pledge at the website:

http://sens.org/donate

The SENS Research Foundation is a 501(c)(3) charity and all US donations are tax-deductible. Donations from most European Union countries are also tax-deductible, though the details vary by location. Please contact the SENS Research Foundation to find out more.

Together, We Fund Research to Treat the Causes of Aging...

The best destination for charitable donations intended to speed the development of therapies to treat aging is the SENS Research Foundation. This is a noted California 501(c)(3) nonprofit organization that coordinates a diverse portfolio of work in US and European laboratories with the aim of ending frailty and disease in aging. The SENS Research Foundation, and its ally the Methuselah Foundation, have a proven track record in helping to move important rejuvenation technologies from the earliest stages of research to the point of commercial development: therapies capable of repairing and reversing the well-known forms of accumulated cell and tissue damage that are collectively the root cause of aging. Even working prototypes and promising results in animal studies will be good enough to attract far greater funding and attention from larger institutions. The best way to make that happen? Donate to the SENS Research Foundation. But don't take our word for it. David Spiegel is a noted researcher who runs the Spiegel Research Group at Yale University and works on glucosepane cross-linking, one of the forms of tissue damage that causes aging. In his view, funding from the SENS Research Foundation has been instrumental to the creation of important progress in this field:

The SENS Research Foundation funding has been critical to our work studying and developing methods to reverse the effects of advanced glycation end-products (AGEs) in aging. AGEs are non-enzymatic modifications that build up on proteins as people age, leading to inflammation and tissue damage. Early on, our lab focused significant effort on developing the first total synthesis of glucosepane - a major AGE cross-link found in human tissues - but we were unable to find funding from any of the traditional sources. The SENS Research Foundation came to our aid, and supported this research for over 5 years. In 2015, our glucosepane synthesis efforts were published in Science, and lay a foundation for developing drugs capable of detecting and reversing tissue damage in aging. We are deeply grateful to the SENS Research Foundation and Fight Aging! for all of their support and look forward to exciting, life-extending work to come!

...to Ensure the Development of Medicine for Aging

Funding early stage research today produces big wins tomorrow. Success in research requires philanthropic support at the outset, and that is where we come in, but once the first results are demonstrated then other groups become willing to step in to help. Success breeds success. This has already happened for programs administered by the SENS Research Foundation: past donors have seen the research they funded take root and grow. Back in 2008, SENS programs, then running at the Methuselah Foundation, directed donor funding to help support the work of the Corral-Debrinski laboratory in Paris in developing mitochondrial repair biotechnologies relevant to the creation of rejuvenation therapies. This was a success, drew in further funding, and by 2013 the company Gensight was founded to commercialize this technology for the treatment of hereditary mitochondrial disorders. Today Gensight is directing tens of millions of dollars in venture funding in order to supply mitochondrial repair therapies to the market. All that needs to happen next is to repurpose the resulting technology platform for use in aging, and this is exactly the sort of result that can arise from a few tens of thousands of dollars spent well on early stage research, networking, and support.

Similarly, from 2014 to 2016 senescent cell research transitioned from a scattering of slow-moving, thinly funded research programs, some of which the SENS Research Foundation helped to make possible, to rapid and well-funded commercial development in a group of startup companies, one of which, UNITY Biotechnology, has now raised more than $100 million for this work. This is the sort of result we aim for when we support the SENS Research Foundation: to see previously languishing fields relevant to rejuvenation therapies take off in this manner, gaining large-scale funding and widespread support in a short period of time once the tipping point is reached. This process is underway at earlier stages for a range of other important fields, the result of recent years of philanthropic funding by the SENS Research Foundation and its supporters. For example, the startup Human Rejuvenation Technologies launched in 2015 to work on treatments for atherosclerosis based on results from SENS Research Foundation in-house programs for breaking down harmful intracellular aggregrates. Further, the age-related cross-link breaking research program funded by donations to the SENS Research Foundation has started to produce results, with a paper published in the prestigious journal Science.

So bear this in mind. When you contribute to the SENS Research Foundation you are helping to build the foundation for the next decade of important medical advances.

Our Donations Make a Meaningful Difference

Early stage medical biotechnology research of the sort carried out at the SENS Research Foundation costs little nowadays in comparison to the recent past. The cost of tools and techniques in biotechnology has plummeted in the past decade, even while capabilities have greatly increased. A graduate student with $20,000 can accomplish in a few months what would have required a full laboratory, years, and tens of millions of dollars in the 1990s. All of the much-lamented great expense in modern medicine lies in clinical translation, the long and drawn out process of trials, retrials, marketing, and manufacturing that is required to bring a laboratory proof of concept into clinics as a widely available therapy.

The SENS Research Foundation is focused on early stage research, following a plan that leads to technology demonstrations in the laboratory. With a proof of concept rejuvenation therapy the world will beat a path to their doorstep in order to fund clinical translation. For an example, look no further than the $100 million raised by UNITY Biotechnology for senescent cell clearance in 2016, very soon after showing extension of life and health benefits in mouse studies. We'd like to see all of the SENS portfolio reach this point, as all of its various lines of research are needed for comprehensive rejuvenation. The real challenge lies in raising the funds needed to get to the point at which commercial investment is a reality, and in the early stages a few tens of thousands of dollars means the difference between a significant project delayed indefinitely or completed successfully.

To pick one example, in 2013 the community raised $20,000 to fund cutting edge work in allotopic expression of mitochondrial genes, a potential cure for the issue of mitochondrial damage in aging. That was enough to have a skilled young researcher work on the process for two of the thirteen genes of interest over a period of months, and bring it to a successful conclusion. It really is that cheap given an existing group like the SENS Research Foundation with diverse connections and access to established laboratories. Those established laboratories also benefit from donations at this level. Noted researchers Michael and Irina Conboy at UC Berkeley had this to say about our fundraising:

In 2014 our lab hit a gap in funding and was in dire need of money to keep a postdoc for just a few more months, to finish up work on the rejuvenating effects of oxytocin. The SENS Research Foundation came through with the funds and we were able to finish and publish the work in Nature Communications. While maybe not the direct path to immortality, that project indicated an effective drug for muscle and bone regeneration (and probably other tissues as well), that is generally recognized as safe. Now the SENS Research Foundation funds our postdoc working on a mouse-sized blood-fraction exchange device project, and a cellular senescence collaboration. So we truly appreciate SENS and Fight Aging! and the donors; even a little support at the right time can make a huge difference in outcome.

Your donations make a real difference.

We Lead the Way by Raising Funds

Fight Aging! strongly supports the Strategies for Engineered Negligible Senescence (SENS) research programs, largely coordinated by the SENS Research Foundation, but also now appearing independently elsewhere in the research community. This work approaches the treatment of aging from the point of view of damage repair: certain well known and well described forms of cellular and molecular damage accumulate as a side-effect of the normal operation of metabolism, and together these cause all of the suffering and frailty of degenerative aging. If we can build the proposed means to repair that damage then the resulting treatments will produce actual rejuvenation: reversal of the signs of aging, prevention of age-related disease, and additional healthy and productive years of life.

Funding is the present limit to progress in SENS rejuvenation research. Given that SENS is supported by many of the luminaries in modern medical research, why is it the case that these programs are not presently funded with billions by large institutions? The answer is that after a mere ten years of small-scale research for most of its programs SENS is still comparatively new, all change in the research establishment is painfully slow, and sources of large-scale funding are exceedingly conservative. Successes like the present growth in senescent cell clearance research and development have yet to sink in, or are not yet broadly recognized as an important, sweeping change in the approach to medicine. Thus major funding institutions wait for other people to lead the way by forming communities and raising funds to carry out the initial proof of concept research programs. That means us. We light the beacon and point other groups towards the best and most promising research programs capable of leading to an end to the pain and suffering that accompanies aging. As we succeed in strengthening the SENS research programs, others will join in to reinforce our success, just as happened for research into ways to remove senescent cells. This is how change happens in medical research: every friend persuaded and every dollar donated makes a difference.

In 2016, $440,000 Raised

In 2016, Michael Greve put up a $150,000 challenge fund for the main SENS Research Foundation fundraiser, which was matched and exceeded for a total of $440,000 due to a number of large last-minute donations. We also launched the SENS Patron effort: Josh Triplett, Christophe and Dominique Cornuejols, and Fight Aging! assembled a further $36,000 matching fund to match a year of donations for anyone who signed up as a SENS Patron by pledging monthly donations to the SENS Research Foundation. A little over $32,000 of that match was claimed in November and December of 2016. It was a tough year for fundraising by the time December rolled around, given that more than $120,000 had been given by our community just months earlier in other, separate crowdfunding initiatives for senescent cell testing and the SENS Research Foundation OncoSENS program. It is pleasing to see that we continue to rise to the challenge.

In 2015, $250,000 Raised

In the last quarter of 2015, Fight Aging!, Josh Triplett, Christophe and Dominique Cornuejols, Michael Greve of forever-healthy.org, and Stefan Richter collaborated to create a $125,000 matching fund for SENS donations. From October 1st to December 31st 2015 $1 donated to SENS rejuvenation research was matched with $1 from the fund. It was our challenge to the community: help us raise a grand total of $250,000 for research in a few short months. These are critical years in the development of this field, a disruptive period of transition from the ineffective approaches of the past to a near future of far more effective means of treating aging. The greater the funding for early-stage research, the faster the progress towards treatments for aging.

In 2014, $150,000 Raised

The 2014 Fight Aging! Fundraiser ran in the last quarter of the year to benefit the SENS Research Foundation, a noted California non-profit that coordinates work in US and European laboratories with the aim of ending frailty and disease in aging. The following individuals and organizations stepped up to make a difference by establishing a $100,000 challenge fund: Christophe and Dominique Cornuejols, Dennis Towne, HÃ¥kon Karlsen, Jason Hope, Methuselah Foundation, Michael Achey, Michael Cooper, and Fight Aging! With the help of these generous donors we then challenged the grassroots community to donate a further $50,000 in the last three months of 2014 - and more than 500 people came together to do just that. Of note is that immediately following our fundraising success, Ronny Hatteland set up another $10,000 matching fund for the last weeks of year: this is an energetic community when it sets its mind to something.

In 2013, $60,000 Raised

In 2013 we ran a very impromptu fundraiser in the last months of the year, responding to a challenge from the SENS Research Foundation. Jason Hope, Methuselah Foundation, and Fight Aging! put together a $45,000 matching fund and numerous members of the community donated a further $15,000 in response to our call to action. This wasn't the only fundraising for SENS rejuvenation research programs that year: Michael Cooper also put up a $15,000 matching fund at the end of the year, and the Longecity community earlier raised $21,000 to fund a specific research project relating to repair of mitochondrial DNA damage.

Fundraising Posters

Do Something About It Poster #1: 4200 x 2800px

Do Something About It Poster #2: 4200 x 2800px

Support Rejuvenation Research Poster: 4200 x 2800px

Fund More Research Poster: 4200 x 2800px

Choose Life: Scientists Work to End Frailty Poster: 4200 x 2800px

Choose Life: No More Frailty Poster: 4200 x 2800px

Last updated: October 22nd 2016