Here's a somewhat more concise article from the LEF News on recent research on the longevity of yeast. It all ties in to the genetics of calorie restriction: why does it work, how does it work? If we know how low calorie diets cause changes in gene expression in the body -- which they appear to do -- then this opens the door to faking it. Therapies could be developed to more reliably induce the same life-extending changes. No need for the low calorie diet, and there would still be the possibility of further improvement and understanding of health and lifespan. This recent genetic research into calorie restriction is very exciting indeed.