An article from Boulder News offers a look at the practice of taking hormone supplements in an attempt to retard aging. There are some interesting quotes; I think that the important lesson to take away is that the science is very uncertain. There are unknown risks associated with the long-term use of hormone supplements. This is one of the reasons I advise people to stick to proven healthy life extension strategies. (Like calorie restriction). It is worth noting that the people who try strategies like hormone supplementation usually take very good care of their health in other ways as well. They may look healthy and young, but it is hard say why.