Mechanism of Calorie Restriction Revealed?

At Betterhumans, an article on recent noteworthy research into the biochemistry of calorie restriction. As we should all know by now, calorie restriction has long been shown to extend healthy lifespan and drastically increase resistance to the common diseases of aging. It looks like MIT scientists have definitively pinned down one simple mechanism whereby calorie restriction activates a known anti-aging gene - it remains to be seen whether this is the only or principle mode by which calorie restriction operates to extend healthy life span.

Link: http://www.betterhumans.com/News/news.aspx?articleID=2003-12-31-4