The latest webcast from SAGE Crossroads is a discussion of the power of advocacy to shape the path of medical research. For example, much of the tenfold growth at the National Institute on Aging over the past two decades has been due to advocacy for Alzheimer's research. Insights into the way in which the NIH and NIA work - given their enormous influence over their course of aging and anti-aging research - are always appreciated. Large organizations are only now thinking about backing real anti-aging research in any meaningful way. The weight of science and advocacy should overcome remaining reluctance before the end of the decade.