Reuters reports on a study confirming that calorie restriction can extend healthy life span in mice even if started in old age. Most scientists expect calorie restriction results in animals to translate well to humans, based on work done to date. This study was funded by BioMarker Pharmaceuticals, a company working on medicine to reproduce that beneficial effects of calorie restriction without the dieting. Scientists understand far more about the way in which calorie restriction works these days, so we should start to see results in a few years. In particular, the work on changes in gene expression that occur with calorie restriction is interesting and promising.