The Financial Times is carrying a better article about recent research into calorie restriction (CR). It is looking ever more likely that the mechanism responsible for the beneficial effects of CR has actually been pinned down, and researchers are well on their way to a complete understanding. The first products resulting from this knowledge are likely to be anti-obesity therapies, commercialized by Elixir Pharmaceuticals. As Leonard Guarente says, however, "it would be interesting to see what would happen if an anti-obesity drug is out there that is known to extend life. Would people use it only to fight fat?" I think we all know the answer to that question.