This article from STLtoday takes a look at the biochemistry of fat cells and how fat influences the body and brain. Too much fat in your body is a recipe for risk. Being overweight greatly raises your chances of developing almost all common (and crippling) age-related conditions as you get older - diabetes, Alzheimer's, heart disease and many others have all been linked to excess weight. Some of the known benefits of a calorie restriction diet - resistance to age-related disease and extended healthy life spans - may derive from the fact that practitioners tend to have little body fat. It's certainly worth a closer look if you are interested in improving your long term health and longevity.