Science Blog talks about resveratrol in the context of calorie restriction, extended longevity, and the underlying biochemistry of it all. There are definite signs of complexities that researchers don't yet understand: "Sirtuins don't extend life when coupled with real caloric restriction. In fact, when flies on a low-calorie diet ate resveratrol and fisetin, they didn't live any longer than average flies. Another surprising discovery was the fact that flies feasting on sirtuins didn't have problems reproducing -- a negative side effect of caloric restriction." More research is needed - and perhaps a more ambitious research direction. We're still spending far too much time on old school methods that just don't measure up to what is possible.