Ben Bova, science fiction author and columnist, takes a look at calorie restriction as a part of his latest outing at the Naples Daily News. "For several years now, biologists have known that certain organisms can extend their life spans significantly — more than 50 percent, in some cases — by severely restricting their intake of food." Given the latest research results, it seems very likely that calorie restriction works to extend life span in humans as well - if not to the same extent. Meanwhile, scientists are closing in on an understanding of the mechanisms by which calorie restriction improves health and extends life span. I expect to see fairly reliable calorie restriction mimetics appearing in the drug pipeline within the next five years.