SAGE Crossroads On Mitochondria

The latest SAGE Crossroads weekly article discusses mitochondria, our cellular powerhouses: "Recent studies have implicated unchecked mitochondrial decay in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), obesity, diabetes, and aging itself ... some studies have suggested that one of our most popular all-purpose panaceas--exercise--acts in part by slowing and perhaps suspending the mitochondrial countdown." Repairing, replacing or moving mitochondrial DNA is on biogerontologist Aubrey de Grey's engineering list. If, for example, we could move mitochondrial DNA into the comparatively well-protected cell nucleus, we would be in much better shape to resist ongoing damage.



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