It was only a matter of time before the vanity anti-aging marketplace turned its attention to calorie restriction (CR), given the very impressive recent results from ongoing human studies. So here we go: "Histomorphological changes resulting from intrinsic aging affected some of the studied variables in the rat skin, and these changes were delayed or prevented by CR. Some stimulatory effects, such as increased densities of fibroblasts and capillary profiles and higher values of connective tissue fibers resulting from CR, were also observed. Cutaneous morphological changes due to natural aging in this rat model seem to be modified by physiological or metabolic alterations imposed by CR." In other words, CR slows skin aging - it will be interesting to see how the industry decides to try and sell this.