On Upb10 And Telomeres

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The LEF News is reprinting an interesting illustration of cellular complexity. "Genomic instability, particularly in the regions at the ends of the chromosomes known as telomeres, has been linked to aging in humans and an elevated risk for aging-related diseases, the most prominent of which is cancer. ... an enzyme known as Ubp10 plays a vital role in protecting the telomeric regions of the genome from potential destabilizing molecular events. ... Interestingly, Ubp10 appears to work similarly and in concert with another enzyme called Sir2 ... Sir2 has also been associated with promoting genomic stability, and some studies have linked it intriguingly to the aging process. Some studies, for example, have suggested that low-calorie diets that extend life also boost Sir2 activity dramatically."

Link: http://www.lef.org/news/LefDailyNews.htm?NewsID=1856&Section=AGING