SAGE Crossroads takes a look at our current understanding of what happens to stem cells with age - and what could be done to rejuvenate their capability to heal. "Stem cells are still there in old age; they just seem to be quiescent ... [this is] the next huge area in stem cell research." Scientists have demonstrated that they "can manipulate the stem cell environment to improve the function of its residents. ... After researchers delineate the orchestra of signals that guide stem cells, perhaps we'll no longer have to cover our gray. We'll be able to use stem cells to put the bounce and shine back into tissues in addition to our hair." The prospect of using biochemical cues to reactivate aging stem cells is intriguing, to say the least.