Fishing For Longevity Genes

From PLoS Genetics, the results of a search for more genes affecting longevity in nematode worms. Researchers have "identified 23 new longevity genes affecting signal transduction, the stress response, gene expression, and metabolism and assigned these genes to specific longevity pathways. ... Surprisingly, of the new genes that have conserved sequence domains, only one could not be associated with a known longevity pathway. Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias." This study should contribute to the scientific understanding of calorie restriction and other metabolic tweaks that can extend healthy life span. While unlikely to lead to radical life extension, increasing longevity by improving metabolism is plausible for the near future of medical science.

Link: http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0010017

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