Following on from more modest trials of first generation stem cell therapies for heart disease, a 1200-member trial is to begin in Brazil. "As for the patients, they will certainly have better quality of life with less need to use medications and fewer hospital visits. And it is also estimated that the new treatment could save as many as 200,000 lives over a three year period." Accumulated damage to heart tissue kills many, many people - approximately 2000 each and every day in the US alone. The heart is a good place to start on regenerative medicine. It is a comparatively unsophisticated organ, requiring less tailored, complex therapies - and any effective therapy will bring health benefits and additional years of healthy life to large numbers of people.