What is the logical endpoint for stem cell medicine as a mature field in 2030 or 2050? This EMBO Reports paper takes a look: "Doctors thawed a frozen tube of Jon's personalized stem cells - established in 2013 from embryonic stem cells created through somatic nuclear transfer - and injected them ... Thanks to a sophisticated cocktail of growth factors, the new stem cells target the damaged area and rapidly get to work, perfectly rebuilding a youthful heart. Several weeks later, Jon is discharged in excellent health. Regenerative medicine provided him with a new kidney ten years ago, and subsequent double knee regeneration gave him renewed mobility. Now his new heart will soon have him running a six-minute mile again. Jon Sigurdsson is 100 years old."