Neurodegeneration And Quinolinic Acid

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(From Medical News Today). Interesting news from Alzheimer's researchers: "We found that all of the brains of dementia patients showed quinolinic acid neurotoxicity. This acid kills nerve cells in the brain, leading to brain dysfunction and ultimately death. ... Quinolinic acid is part of a biochemical pathway called the kynurenine pathway. The activation of that pathway is also found in other major brain diseases including Huntington's disease, stroke, dementia and schizophrenia. ... There are several drugs which can block this pathway, which are already under investigation by our laboratory and others ... Quinolinic acid may not be the cause of Alzheimer's disease, but it plays a key role in its progression ... While we won't be able to prevent people from getting Alzheimer's disease, we may eventually, with the use of drugs, be able to slow down the progression."

Link: http://www.medicalnewstoday.com/medicalnews.php?newsid=28644