Gene Therapy Versus Atherosclerosis

Via ScienceDaily, news of another promising gene therapy in the works: "Cardiology researchers at Cedars-Sinai Medical Center have found that a single injection of a harmless virus engineered to carry a beneficial, mutant gene enabled animals to manufacture their own supply of the gene's protein product that protects against plaque buildup in blood vessels. As a result, the amount of plaque was significantly reduced, as was an immune reaction that can lead to plaque buildup and rupture, which can cause a blocked artery and heart attack or stroke. ... a clinical trial was conducted in humans with similar results. After five weeks of once-a-week injections, [the protein produced by the gene] significantly shrank plaque in coronary arteries. The protein appeared to actually remove bad cholesterol, even from sites on arteries where plaque had accumulated."

Link: http://www.sciencedaily.com/releases/2005/11/051126140633.htm

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