From Medpage Today, an interesting look at the roots of age-related diabetes: "when type 2 diabetics have children, those offspring may get stuck with an inheritance of reduced mitochondrial activity in muscle cells. That, the researchers said, can lead to insulin resistance even when the progeny are young, lean, and have normal glucose levels. The finding adds to the weight of evidence suggesting that mitochondrial dysfunction in insulin-resistance pathways may play a major role in the development of type 2 [usually age-related] diabetes. ... These data provide new insights into the earliest defects that may be responsible for the development of type 2 diabetes."