Medical News Today has a better piece on the ten new longevity-related genes discoved in yeast: "the researchers tested two - Tor1 and Sch9 - to confirm their connection to caloric restriction. One test combined caloric restriction with the genetic mutation to Tor1 that reduced signaling on the TOR pathway. They saw lifespan increases in the resulting yeast cells that were about the same as a cell that had just the Tor1 mutation, indicating that the mutation was doing the same thing as caloric restriction. The TOR pathway is evolutionarily conserved, meaning it is common to many lifeforms. We'd like to know if this is the pathway through which caloric restriction affects lifespan. We think this may be why mice live longer with calorie restriction, because of TOR pathway down-regulation."