CBS News recently aired a segment on the practice of calorie restriction (CR) for healthy life extension: "Definitely his life expectancy is higher than an average American. ... Doctors like Fontana are conducting long-term studies of C.R. They're convinced it protects against major diseases. Dr. John Holloszy, principal investigator, agrees. 'There's no chance of them getting type 2 diabetes, they have very low blood pressure, and the risk of them developing cancer is markedly decreased.'" That said, I don't think their comments on exercise are helpful - exercise affects a range of metabolic processes over the long term in ways I cannot see diet choices replicating. It's perfectly possible to both practice CR and exercise moderately - you certainly should if you'd like to see as much as possible of the real anti-aging medicine of future decades!