Insulin, Fat, Aging, Calorie Restriction

Fight Aging!

Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved. Find out how to help »

(Via the LEF News). Synthesis of threads of research into an understanding of a complex system is very rewarding; progress is being made towards this goal for metabolism and longevity: "Caloric restriction and leanness have been shown to increase longevity in organisms ranging from yeast to mammals. Adipose tissue seems to be a pivotal organ in the aging process and in determination of lifespan ... fat-specific disruption of the insulin receptor gene is sufficient to increase lifespan in [mice], suggesting that reduced adiposity, even in the presence of normal or increased food intake, can extend lifespan. The model also suggests a special role for the insulin-signaling pathway in adipose tissue in the longevity process. ... In the control of human aging and longevity, one of the striking physiological characteristics identified in centenarians is their greatly increased insulin sensitivity even compared with younger individuals."

Link: http://www.lef.org/news/LefDailyNews.htm?NewsID=3285&Section=AGING